Key result
Male sex and Native American or Asian Pacific Islander race are associated with an increased risk of major adverse cardiovascular-cerebral events and mortality in patients with NAFLD.
Why the study?
Does male sex and specific racial background increase the risk of major adverse cardiovascular-cerebral events (MACCE) and cardiovascular mortality in patients with non-alcoholic fatty liver disease?
Does male sex and specific racial background increase the risk of major adverse cardiovascular-cerebral events (MACCE) and cardiovascular mortality in patients with non-alcoholic fatty liver disease?
This editorial highlights the need for heightened cardiovascular risk assessment in men and specific racial groups with NAFLD due to their increased risk of MACCE and mortality.
Non-alcoholic fatty liver disease (NAFLD) has emerged as the commonest cause of chronic liver disease worldwide in recent years. With time, our understanding of NAFLD has evolved from an isolated liver condition to a systemic disease with significant manifestations beyond the liver. Amongst them, cardiovascular diseases (CVDs) are the most important and clinically relevant. Recent research supports a strong independent link between NALFD and CVD beyond the shared risk factors and pathophysiology. Female sex hormones are well known to not only protect against CVD in pre-menopausal females, but also contribute to improved adipose tissue function and preventing its systemic deposition. Recent research highlights the increased risk of major adverse cardiovascular-cerebral events (MACCE) amongst male with NAFLD compared to females. Further, racial variation was observed in MACCE outcomes in NAFLD, with excess mortality in the Native Americans and Asian Pacific Islanders compared to the other races.
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Batta et al. (2024) conducted an editorial in Non-alcoholic fatty liver disease (NAFLD). Male sex vs. Female sex was evaluated on Major adverse cardiovascular-cerebral events (MACCE) and mortality. Male sex and Native American or Asian Pacific Islander race are associated with an increased risk of major adverse cardiovascular-cerebral events and mortality in patients with NAFLD.
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