Key result
This review highlights evidence from prospective clinical and Mendelian randomization studies suggesting a potential causal relationship between nonalcoholic fatty liver disease and cardiovascular disease.
Why the study?
Cardiovascular disease is the leading cause of mortality in patients with NAFLD, but whether NAFLD is a causal risk factor for CVD remains debated.
Is nonalcoholic fatty liver disease (NAFLD) a causal risk factor for cardiovascular disease (CVD)?
Is nonalcoholic fatty liver disease (NAFLD) a causal risk factor for cardiovascular disease (CVD)?
This review highlights the emerging evidence that NAFLD may be a causal risk factor for cardiovascular disease, emphasizing the need to address CVD risk in NAFLD management.
NAFLD's causal role in CVD remains debated; leaves open whether liver-targeted therapies independently reduce events.
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide that poses a significant threat to human health. Cardiovascular disease (CVD) is the leading cause of mortality in NAFLD patients. NAFLD and CVD share risk factors such as obesity, insulin resistance, and type 2 diabetes. However, whether NAFLD is a causal risk factor for CVD remains a matter of debate. This review summarizes the evidence from prospective clinical and Mendelian randomization studies that underscore the potential causal relationship between NAFLD and CVD. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.
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Li et al. (2023) conducted a review in Nonalcoholic fatty liver disease (NAFLD) and Cardiovascular disease (CVD). Nonalcoholic fatty liver disease (NAFLD) was evaluated on Cardiovascular disease (CVD). This review highlights evidence from prospective clinical and Mendelian randomization studies suggesting a potential causal relationship between nonalcoholic fatty liver disease and cardiovascular disease.
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