Key result
NAFLD is independently associated with CVD and novel cardiovascular risk factors in the Russian population.
Highlights NAFLD as a significant, independent risk factor for cardiovascular disease, emphasizing the need to address both traditional and novel risk factors in these patients.
The problem of non-alcoholic fatty liver disease (NAFLD), which is an independent risk factor for a number of cardiovascular diseases (CVD), is considered. The high prevalence of cardiovascular risk factors is demonstrated in patients with NAFLD in Russian population. Common pathophysiological mechanisms of NAFLD and CVD (insulin resistance and excessive accumulation of lipids in the liver) are discussed. The "new" risk factors (thickening of the pericardial fat, endothelial dysfunction, thickening of the intima-media complex, increase in plasma level of C-reactive protein and others.) are found in patients with NAFLD, along with a greater prevalence of traditional factors of CVD risk (obesity, diabetes, metabolic syndrome and etc.). The relationship of NAFLD with atherosclerosis, dyslipidemia, features of bile acids metabolism in NAFLD and ability to influence these components are also considered.
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Драпкина et al. (2016) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. Non-alcoholic fatty liver disease (NAFLD) was evaluated. Non-alcoholic fatty liver disease is an independent risk factor for cardiovascular diseases, associated with both traditional and novel cardiovascular risk factors in the Russian population.
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