Key result
Noninvasive estimation of a single moving dipole localized the initiation site of cardiac activation with an average error of 16.8 +/- 2.3 mm compared to intracavitary noncontact mapping in a swine model.
Why the study?
Can a single moving dipole (SMD) solution accurately localize the initiation site of cardiac activation compared to intracavitary noncontact mapping in a swine model?
Can a single moving dipole (SMD) solution accurately localize the initiation site of cardiac activation compared to intracavitary noncontact mapping in a swine model?
Noninvasive estimation of a single moving dipole from body surface potential mapping shows potential for localizing focal cardiac events with an average error of approximately 16.8 mm in a swine model.
Hypothesis-generating for noninvasive focal localization in swine; leaves open human validation before clinical mapping use.
The accuracy of localizing the initiation site of cardiac activation by noninvasively estimating a single moving dipole (SMD) was investigated in a swine model. Body surface potential mapping (BSPM) and intracavitary noncontact mapping (NCM) were performed simultaneously during acute left ventricular (LV) endocardial pacing. For each animal, the boundary element model was constructed from preoperative magnetic resonance images (MRI). In each pacing study, the initiation site was localized by inversely estimating the location of an SMD from BSPM data. The results were compared with the precise pacing sites recorded by the NCM system. In total, four pacing sites from two pigs were analyzed, and the averaged source localization error was 16.8 +/- 2.3 mm. The present results indicate the potential of localizing focal cardiac events by estimating single moving dipole.
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Lai et al. (2009) studied Cardiac activation localization (n=2). Single moving dipole (SMD) estimation from body surface potential mapping (BSPM) vs. Intracavitary noncontact mapping (NCM) was evaluated on Source localization error. Noninvasive estimation of a single moving dipole localized the initiation site of cardiac activation with an average error of 16.8 +/- 2.3 mm compared to intracavitary noncontact mapping in a swine model.
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