Key result
123I-MIBG myocardial scintigraphy differentiated probable dementia with Lewy bodies from probable Alzheimer's disease with a sensitivity of 68.9% and a specificity of 89.1% using the automated heart-to-mediastinum ratio.
Why the study?
Does 123I-MIBG myocardial scintigraphy improve diagnostic accuracy in differentiating probable dementia with Lewy bodies from probable Alzheimer's disease?
Population
133 patients aged 55-85 years with clinical diagnoses of probable or possible dementia with Lewy bodies or…
Comparison
123I-meta-iodobenzylguanidine myocardial… vs Clinical diagnosis of probable Alzheimer's…
Design
Cohort, Three readers, unaware of the clinical diagnosis, classified the images
Authors
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May aid differentiation in mild dementia; leaves open prospective validation before routine adoption.
Cross-Sectional (n=133)
Blinded image readers
Yes
Does 123I-MIBG myocardial scintigraphy improve diagnostic accuracy in differentiating probable dementia with Lewy bodies from probable Alzheimer's disease?
Effect estimate: Sensitivity 68.9%, Specificity 89.1%
123I-MIBG myocardial scintigraphy demonstrates high diagnostic accuracy for differentiating dementia with Lewy bodies from Alzheimer's disease, particularly in patients with mild dementia.
Yoshita et al. (2015) conducted a cross-sectional in Dementia with Lewy Bodies vs Alzheimer's disease (n=133). 123I-MIBG myocardial scintigraphy vs. Clinical diagnosis of probable Alzheimer's disease was evaluated on Diagnostic accuracy (sensitivity and specificity) to differentiate probable DLB from probable AD using the automated heart-to-mediastinum ratio (Sensitivity 68.9%, Specificity 89.1%). 123I-MIBG myocardial scintigraphy differentiated probable dementia with Lewy bodies from probable Alzheimer's disease with a sensitivity of 68.9% and a specificity of 89.1% using the automated heart-to-mediastinum ratio.
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