March 1, 1988CirculationOpen Access

Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.

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Why the study?

Does nitroprusside or pinacidil improve myocardial blood flow and reduce infarct size in a canine model of acute myocardial infarction?

Structured PICO

Does nitroprusside or pinacidil improve myocardial blood flow and reduce infarct size in a canine model of acute myocardial infarction?

Population

Instrumented awake dogs subjected to 4 hr of left anterior descending coronary artery occlusion and 20 hr of reperfusion

Intervention

Intravenous nitroprusside or pinacidil beginning 40 min after the onset of coronary artery occlusion and continuing throughout the occlusion and the first hour of reperfusion, titrated to decrease mean aortic pressure by 25 mm Hg

Comparator

Intravenous normal saline

Outcome

Myocardial blood flow and infarct sizesurrogate

In a canine model of acute myocardial infarction, nitroprusside increased ischemic myocardial blood flow and reduced infarct size, whereas the potent coronary vasodilator pinacidil did not.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports nitroprusside investigation in ischemia; animal data leave human translation open.

Cite This Study

Imai et al. (1988) studied this question.

synapsesocial.com/papers/6a20d56edc4e16663149c990 https://doi.org/10.1161/01.cir.77.3.705

View Full Paper

Ask AI

Bookmark

Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.

Structured PICO

Discussion

Implication

Cite This Study

Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider