May 13, 1982New England Journal of Medicine
Effect of Short-Term Infusion of Sodium Nitroprusside on Mortality Rate in Acute Myocardial Infarction Complicated by Left Ventricular Failure
Why the study?
Does a 48-hour infusion of sodium nitroprusside reduce mortality in men with acute myocardial infarction and elevated left ventricular filling pressure?
Population
812 men with presumed acute myocardial infarction and left ventricular filling pressure of at least 12 mm Hg
Comparison
48-hour infusion of sodium nitroprusside vs Placebo
Design
RCT, randomized, double-blind
Follow-up
13 weeks
Authors
Discussion
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Member takes
Implication
Nitroprusside does not reduce mortality in acute MI with elevated filling pressure and may increase early risk; challenges routine vasodilator use.
Structured PICO
Does a 48-hour infusion of sodium nitroprusside reduce mortality in men with acute myocardial infarction and elevated left ventricular filling pressure?
P
Population
812 men with presumed acute myocardial infarction and left ventricular filling pressure of at least 12 mm Hg
I
Intervention
48-hour infusion of sodium nitroprusside
C
Comparator
Placebo
O
Outcome
Mortality rate at 21 days and at 13 weekshard clinical
Routine use of short-term sodium nitroprusside infusion does not improve overall mortality in acute MI with elevated LV filling pressure, and may be harmful if initiated early.
Cite This Study
Cohn et al. (1982) studied this question.