Key result
Nitroprusside improves hemodynamic indexes in patients with acute myocardial infarction, but its effects on infarct size and long-term mortality remain unclear.
Why the study?
Does nitroprusside reduce mortality in patients with acute myocardial infarction when given during the initial 24 to 48 hours of hospitalization?
Does nitroprusside reduce mortality in patients with acute myocardial infarction when given during the initial 24 to 48 hours of hospitalization?
This editorial discusses the rationale and mixed prior evidence for using nitroprusside to reduce mortality in acute myocardial infarction.
This issue of the Journal includes reports of two clinical trials in patients with acute myocardial infarction,1 , 2 testing the hypothesis that nitroprusside, a vasodilator, will reduce mortality when given during the initial 24 to 48 hours of hospitalization.Nitroprusside has been tested in both animal models and patients with myocardial infarction, with mixed results; investigators have reported improvement, no change, and worsening of ST-segment elevation, an index of ischemia. Very little is known about the effect of nitroprusside on infarct size or long-term outcome after infarction. It is agreed that hemodynamic indexes improve with nitroprusside in patients with myocardial infarction . . .
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Eugene R. Passamani (1982) conducted an editorial in Acute myocardial infarction. Nitroprusside was evaluated on Mortality. Nitroprusside improves hemodynamic indexes in patients with acute myocardial infarction, but its effects on infarct size and long-term mortality remain unclear.
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