Preclinical Evidence of Alzheimer Changes
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Overview
Cohort study assesses correlations between CSF biomarkers and glucose metabolism in healthy individuals, indicating early Alzheimer changes.
Key Points
- To explore relationships between CSF biomarker levels and cerebral glucose metabolism in early Alzheimer disease.
- Cohort study design with 20 healthy individuals aged 46 to 83 years.
- Lumbar CSF sampling and FDG-PET imaging for measuring cerebrospinal fluid biomarkers and cerebral glucose metabolism.
- Correlations analyzed using voxel-based and volume-of-interest methods.
- Significant negative correlations between CSF tau and ptau(181) levels and CMRglu in key brain regions.
- Positive correlation between CSF Abeta(42) levels and CMRglu in the inferior temporal cortex confirmed.
- Findings suggest early tau and Abeta abnormalities may relate to synaptic changes in Alzheimer-vulnerable areas.
Cite This Study
Petrie et al. (2009) studied this question.