February 1, 1995Journal of Biological ChemistryOpen Access

A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

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Structured PICO

Population

actomyosin-S1 ATPase and TnI-depleted skinned muscle fibers

Intervention

mutant (TnID57•TnC•TnT) Tn complex

Comparator

wild type (TnI•TnC•TnT) Tn complex

Outcome

Ca2+ regulation of actomyosin-S1 ATPase activity and reconstitution of skinned muscle fiberssurrogate

The study reveals a novel dual role for Ca2+ binding to TnC, involving both the release of ATPase inhibition by TnI and the activation of ATPase through direct interaction with TnT.

Discussion

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Implication

Animal troponin data remain hypothesis-generating; leaves open whether TnT-TnC interaction translates to human cardiomyopathy therapies.

Cite This Study

Potter et al. (1995) studied this question.

synapsesocial.com/papers/6a20d6d5f76165bc1becb66f https://doi.org/10.1074/jbc.270.6.2557

View Full Paper

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A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

Structured PICO

Discussion

Implication

Cite This Study

A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider