May 1, 1992AJP Cell Physiology

Regulation of agonist-evoked [Ca2+]i oscillation by intracellular Ca2+ and Ba2+ in AR42J cells

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Population

Single AR42J cells

Design

Preclinical

Authors

BZB. X. ZhangSouthwestern Medical Center HZHuimin ZhaoShanghaiTech University PLP A LoessbergThe University of Texas Southwestern Medical Center

Discussion

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Implication

Interspike [Ca2+]i thresholds modulate oscillations in AR42J cells; hypothesis-generating for Ca2+ signaling, requires in vivo validation before broader relevance.

Structured PICO

Population

Single AR42J cells

Intervention

Variations in intracellular Ca2+ ([Ca2+]i) and Ba2+ ([Ba2+]i) imposed by gradual activation of entry through voltage-activated Ca2+ channels (VACC) using high K+, BAY K 8644, or Ba2+

Outcome

Agonist-evoked [Ca2+]i oscillations (frequency and inhibition)surrogate

Intracellular calcium levels between spikes play an important role in regulating agonist-evoked calcium oscillations in AR42J cells.

Cite This Study

Zhang et al. (1992) studied this question.

synapsesocial.com/papers/6a20d746dc4e16663149caae https://doi.org/10.1152/ajpcell.1992.262.5.c1125

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Implication

Interspike [Ca2+]i thresholds modulate oscillations in AR42J cells; hypothesis-generating for Ca2+ signaling, requires in vivo validation before broader relevance.

Regulation of agonist-evoked [Ca2+]i oscillation by intracellular Ca2+ and Ba2+ in AR42J cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of agonist-evoked [Ca2+]i oscillation by intracellular Ca2+ and Ba2+ in AR42J cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider