August 11, 1990Nucleic Acids ResearchOpen Access

Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA

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Population

Oligoribonucleotides derived from the satellite RNA of tobacco ringspot virus

Comparison

Replacement of the usual CpA junction with a CpU… vs Usual CpA junction oligoribonucleotide

Design

Preclinical

Authors

JBJamal M. BuzayanUniversity of California, Davis HTHans Van TolUniversity of California, Davis PFPaul A. FeldsteinUniversity of California, Davis

Discussion

Member takes

Implication

A26 substitution may stabilize therapeutic RNAs; leaves open validation in mammalian models and clinical translation.

Structured PICO

Population

Oligoribonucleotides derived from the satellite RNA of tobacco ringspot virus

Intervention

Replacement of the usual CpA junction with a CpU junction and partial/complete rATP alpha S-substitution

Comparator

Usual CpA junction oligoribonucleotide

Outcome

Autolytic cleavage efficiencysurrogate

Identified a specific non-junction phosphodiester (A26) that strongly influences the autolytic processing reaction of satellite RNA-derived oligoribonucleotides.

Cite This Study

Buzayan et al. (1990) studied this question.

synapsesocial.com/papers/6a20d79bf76165bc1becb7bf https://doi.org/10.1093/nar/18.15.4447

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Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider