Why the study?
Does in vivo adventitial expression of recombinant eNOS gene via CSF injection improve cGMP production and bradykinin-induced relaxations in canine cerebral arteries?
Population
Canine model (cerebral arteries)
Comparison
Replication-incompetent adenoviral vector… vs Adenoviral vector encoding beta-galactosidase…
Design
Preclinical
Follow-up
24 hours
Authors
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Demonstrates feasibility of CSF-mediated eNOS gene delivery in canine arteries; leaves open clinical translation for cerebrovascular disorders.
Does in vivo adventitial expression of recombinant eNOS gene via CSF injection improve cGMP production and bradykinin-induced relaxations in canine cerebral arteries?
Perivascular eNOS gene delivery via the CSF is a feasible approach to functionally express eNOS in large cerebral arteries without interrupting cerebral blood flow.
Chen et al. (1997) studied this question.
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