Population
Endothelium-denuded segments of canine basilar arteries
Comparison
Adenoviral vector encoding eNOS gene incubated… vs Control arteries and arteries transduced with an…
Design
Preclinical
Follow-up
24 hours
Authors
Loading...
Hypothesis-generating for eNOS gene therapy in cerebral vasospasm; requires human trials before any clinical consideration.
Expression of recombinant eNOS in the adventitia of cerebral arteries restores NO-mediated vasodilation in response to various stimuli, suggesting a potential gene therapy approach for conditions with diminished NO bioavailability like cerebral vasospasm.
Tsutsui et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: