Key result
Flavonoids demonstrate strong preclinical antiviral activity against non-polio enteroviruses by targeting various life cycle stages.
Why the study?
Enterovirus causes conditions such as myocarditis and aseptic meningitis, but no approved antiviral drugs exist for enterovirus.
Flavonoids show broad preclinical antiviral activity against non-polio enteroviruses, which are known causes of myocarditis and neurological diseases, by targeting multiple stages of the viral life cycle.
May guide flavonoid research in enteroviral myocarditis; hypothesis-generating and should not yet change practice.
Flavonoids are natural phytochemicals with effective antiviral activity. These natural phytochemicals could act on various viral life cycles. Enterovirus causes aseptic meningitis, encephalitis, hand-foot-and-mouth disease (HFMD), and myocarditis in infants, children, and immunodeficiency patients. However, there are no approved antiviral drugs for enterovirus yet. We reviewed the antiviral activity and molecular mechanism of flavonoids against coxsackieviruses, rhinoviruses, and enterovirus-A71 that contribute to severe neurological and cardiomyopathy, colds, and asthma among viruses in Enterovirus.
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Hwa‐Jung Choi (2023) conducted a review in Non-polio Enterovirus infections (Coxsackieviruses, Rhinoviruses, Enterovirus-A71). Flavonoids was evaluated. Flavonoids demonstrate strong in vitro and in vivo antiviral activity against non-polio enteroviruses by targeting various stages of the viral life cycle.
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