Key result
High-intensity sprint training instituted shortly after MI in rats significantly restored systolic [Ca(2+)](i) (399 vs 350 nM; P<0.0001) and improved sarcoplasmic reticulum function.
Absolute Event Rate: 399% vs 350%
p-value: p=<0.0001
High-intensity sprint training instituted shortly after MI improves intracellular Ca2+ dynamics and SR function in surviving myocytes by modulating phospholamban regulation rather than increasing SR Ca2+-ATPase expression.
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May inform post-MI exercise timing in models; leaves open human translation of Ca2+ restoration.
Zhang et al. (2000) studied Myocardial infarction. High-intensity sprint training (HIST) vs. Sedentary (Sed) was evaluated on Systolic [Ca(2+)](i) (p=<0.0001). High-intensity sprint training instituted shortly after MI in rats significantly restored systolic [Ca(2+)](i) (399 vs 350 nM; P<0.0001) and improved sarcoplasmic reticulum function.
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