Key result
This review discusses the laboratory interference of direct oral anticoagulants (dabigatran, rivaroxaban, and apixaban) on coagulation parameters and methods for measuring their anticoagulant effect.
This review summarizes the laboratory interference of direct oral anticoagulants on coagulation parameters and discusses methods for measuring their anticoagulant effect.
DOAC interference requires cautious coagulation test interpretation in treated patients; leaves open optimal standardized measurement protocols.
Diagnostic of global coagulation parameters is part of the daily clinical routine practice in conservative as well in operative disciplines. The correct interpretation of in vitro test results in context to the ex vivo influence of anticoagulant drugs and the in vivo hemostatic system of the individual patient is dependent on the doctors clinical and laboratory experience. This article shortly reviews the laboratory interference of oral anticoagulants including the target-specific inhibitors dabigatran, rivaroxaban and apixaban on coagulation parameters and discusses the potential of several methods for measuring the anticoagulant effect of the direct oral anticoagulants.
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H. Mani (2014) conducted a review in Patients on direct oral anticoagulants. Direct oral anticoagulants (dabigatran, rivaroxaban, apixaban) was evaluated on Laboratory interference on coagulation parameters. This review discusses the laboratory interference of direct oral anticoagulants (dabigatran, rivaroxaban, and apixaban) on coagulation parameters and methods for measuring their anticoagulant effect.
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