Key result
Microinjection of an antisense oligonucleotide targeting c-fos mRNA into the nucleus tractus solitarii restored impaired baroreceptor reflex sensitivity in hypertensive rats to normotensive levels.
Why the study?
Does microinjection of c-fos antisense oligonucleotide into the nucleus tractus solitarii improve baroreceptor reflex control of heart rate in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR), stroke-prone SHR, Wistar-Kyoto rats, and Sprague-Dawley rats
Comparison
Microinjection into the bilateral nucleus… vs Microinjection of corresponding sense…
Design
Preclinical
Authors
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May identify c-fos as a baroreflex target in hypertension; leaves open translation beyond this rat model.
Does microinjection of c-fos antisense oligonucleotide into the nucleus tractus solitarii improve baroreceptor reflex control of heart rate in spontaneously hypertensive rats?
Elevated basal Fos protein expression in the nucleus tractus solitarii during hypertension contributes to reduced baroreflex response, which can be reversed by targeted antisense oligonucleotide therapy in a rat model.
Chan et al. (1998) studied Hypertension. Microinjection of an antisense oligonucleotide targeting c-fos mRNA into the bilateral nucleus tractus solitarii vs. Sense oligonucleotide, different antisense oligonucleotide, or artificial cerebrospinal fluid was evaluated on Baroreceptor reflex response and Fos-immunoreactive nuclei. Microinjection of an antisense oligonucleotide targeting c-fos mRNA into the nucleus tractus solitarii restored impaired baroreceptor reflex sensitivity in hypertensive rats to normotensive levels.
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