Key result
The CC genotype of the MYL4 rs4968309 polymorphism was significantly associated with an increased risk of atrial fibrillation onset (OR 6.368) and predicted recurrence after catheter ablation.
Why the study?
Mutation of MYL4 was recently reported as responsible for familial atrial cardiomyopathy and AF, but the association between polymorphisms in MYL4 and the onset and recurrence of AF was unknown.
Do MYL4 polymorphisms predict atrial fibrillation onset and recurrence after cryoballoon ablation in patients without structural heart disease?
Observational (n=702)
No
Do MYL4 polymorphisms predict atrial fibrillation onset and recurrence after cryoballoon ablation in patients without structural heart disease?
Odds Ratio: 6.368 (95% CI 2.192–18.502)
p-value: p=0.001
The MYL4 rs4968309 polymorphism is significantly associated with the onset of atrial fibrillation and predicts a higher risk of recurrence following cryoballoon ablation in patients without structural heart disease.
MYL4 rs4968309 CC genotype was associated with AF onset and post-cryoballoon recurrence; hypothesis-generating for risk stratification and requires prospective validation.
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia with serious complications and a high rate of recurrence after catheter ablation. Recently, mutation ofMYL4was reported as responsible for familial atrial cardiomyopathy and AF. This study aimed to determine the association between polymorphism inMYL4with the onset and recurrence of AF. METHODS AND RESULTS: A total of 7 single-nucleotide polymorphisms were selected by linkage disequilibrium and genotyped in 510 consecutive AF patients and 192 controls without structural heart disease. A total of 246 AF patients who underwent cryoballoon ablation had a 1-year scheduled follow-up study for AF recurrence. C allele and CC genotype of rs4968309 and A allele of rs1515751were associated with AF onset both before and after adjustment of covariation (age, sex, hypertension, and diabetes). AF type and left atrial size were different among the genotypes of rs4968309. Moreover, CC genotype of rs4968309 increased susceptibly of AF recurrence after cryoballoon ablation. The prevalence of hypertension was associated with rs1515752, and left atrial size was associated with the genotype of rs2071438. CONCLUSIONS: C allele and CC genotype of rs4968309 inMYL4were associated with AF onset and recurrence. Moreover, the A allele of rs1515751 had a significant association with AF onset. The polymorphisms ofMYL4can predict AF onset and prognosis after ablation in AF patients without structural heart disease.
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Zhong et al. (2019) conducted an observational in Atrial fibrillation (n=702). MYL4 rs4968309 CC genotype vs. MYL4 rs4968309 TT/CT genotypes was evaluated on Atrial fibrillation onset (OR 6.368, 95% CI 2.192-18.502, p=0.001). The CC genotype of the MYL4 rs4968309 polymorphism was significantly associated with an increased risk of atrial fibrillation onset (OR 6.368) and predicted recurrence after catheter ablation.
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