Key result
Aortic valve sclerosis was associated with a 29% increased risk of 5-year all-cause mortality (adjusted HR 1.29) compared to no sclerosis in high-risk coronary artery disease patients.
Why the study?
The relationship between aortic valve sclerosis, cardiovascular risk factors, and mortality in patients with known coronary artery disease remains unclear, with prevalence and long-term mortality unstudied in large high-risk cohorts.
Does the presence of aortic valve sclerosis predict 5-year all-cause mortality in high-risk coronary artery disease patients?
Cohort (n=4,938)
No
Does the presence of aortic valve sclerosis predict 5-year all-cause mortality in high-risk coronary artery disease patients?
Hazard Ratio: 1.29 (95% CI 1.05–1.58)
Absolute Event Rate: 16.6% vs 7.4%
p-value: p=0.014
Aortic valve sclerosis is highly prevalent in high-risk CAD patients and serves as an independent predictor of long-term all-cause mortality, highlighting its potential utility in risk stratification.
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AVSc may aid mortality risk stratification in high-risk CAD; leaves open its incremental value beyond standard models.
Myasoedova et al. (2021) conducted a cohort in High-risk coronary artery disease (n=4,938). Aortic valve sclerosis vs. No aortic valve sclerosis was evaluated on 5-year all-cause mortality (HR 1.29, 95% CI 1.05-1.58, p=0.014). Aortic valve sclerosis was associated with a 29% increased risk of 5-year all-cause mortality (adjusted HR 1.29) compared to no sclerosis in high-risk coronary artery disease patients.
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