Key result
Aortic valve sclerosis was associated with a significantly higher rate of 3-vessel coronary artery disease (40% vs 13.6%, p<0.001) and higher Gensini scores compared to patients without AVS.
Why the study?
Is the presence of aortic valve sclerosis associated with a greater extent of coronary atherosclerosis in patients undergoing coronary angiography?
Observational (n=160)
Is the presence of aortic valve sclerosis associated with a greater extent of coronary atherosclerosis in patients undergoing coronary angiography?
Absolute Event Rate: 40% vs 13.6%
p-value: p=<0.001
Echocardiographic detection of aortic valve sclerosis is strongly associated with a higher angiographic Gensini score and may serve as a surrogate marker for the extent of coronary atherosclerosis.
AVS may flag more extensive CAD on angiography; leaves open its incremental value for risk stratification in observational data.
BACKGROUND: Aortic valve sclerosis (AVS) is considered to be a manifestation of coronary atherosclerosis. Recent studies demonstrated an association between AVS and significant coronary artery disease (CAD). AIM: We sought to determine the association between AVS and the extent of coronary atherosclerosis by means of the Gensini score system, which was calculated to yield a measure of the extent and severity of coronary atherosclerosis in patients referred for coronary angiography. METHODS: A total of 160 consecutive patients referred for coronary angiography were subjected to echocardiography for screening of AVS and coronary risk assessment. Absence (group 1, n = 110) and presence of AVS (Group 2, n = 50) was established. The cardiac risk factors considered in this study were age, gender, family history of CAD, diabetes mellitus, hypertension, hypercholesterolemia and history of smoking. The body mass index was also measured. Atherosclerotic plaque burden was determined using the Gensini score. Significant CAD was defined as >50% reduction in the internal diameter of at least one coronary artery. Multivessel coronary disease was based on the presence of 2- or 3-vessel disease. RESULTS: The AVS patients had a higher rate of 3-vessel disease (AVS group vs. non AVS: 40 vs. 13.6%; p < 0.001). No significant correlations were found between AVS and 1- and 2-vessel disease. Individuals with AVS were found to have a higher Gensini score (40.7 +/- 38.05 vs. 18 +/- 16.4; p < 0.001). Multivariate analysis identified age (p < 0.001), male sex (p = 0.01), triglycerides (p = 0.02), LDL cholesterol (p = 0.001) and Gensini score (p = 0.003) as independent predictors of AVS. CONCLUSION: AVS is strongly interrelated with the coronary angiographic Gensini score. Echocardiographic detection of AVS in patients undergoing coronary angiography can provide a new surrogate marker of the extent of coronary atherosclerosis.
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Soydinç et al. (2006) conducted an observational in Coronary artery disease (n=160). Aortic valve sclerosis vs. Absence of aortic valve sclerosis was evaluated on 3-vessel disease (p=<0.001). Aortic valve sclerosis was associated with a significantly higher rate of 3-vessel coronary artery disease (40% vs 13.6%, p<0.001) and higher Gensini scores compared to patients without AVS.
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