Key result
Aortic valve sclerosis on transthoracic echocardiography was an independent predictor of significant coronary artery disease (OR 3.18; 95% CI 1.52-6.7; p=0.002).
Why the study?
Does the presence of aortic valve sclerosis on echocardiography predict significant coronary artery disease in patients undergoing diagnostic angiography?
Observational (n=357)
Does the presence of aortic valve sclerosis on echocardiography predict significant coronary artery disease in patients undergoing diagnostic angiography?
Odds Ratio: 3.18 (95% CI 1.52–6.7)
p-value: p=0.002
The presence of aortic valve sclerosis on transthoracic echocardiography is a strong independent predictor of significant coronary artery disease, particularly in women and patients under 65 years of age.
Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population-based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R.=3.18; 95% confidence interval 1.52-6.7; p=0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available.
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Hsu et al. (2004) conducted an observational in Suspected coronary artery disease (CAD) (n=357). Aortic valve sclerosis (AVS) was evaluated on Significant coronary artery disease (CAD) (OR 3.18, 95% CI 1.52-6.7, p=0.002). Aortic valve sclerosis on transthoracic echocardiography was an independent predictor of significant coronary artery disease (OR 3.18; 95% CI 1.52-6.7; p=0.002).
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