Mild aortic stenosis was associated with significantly higher rates of left atrial enlargement (32.4% vs 3.3%; P=0.003) and elevated left ventricular filling pressure compared to healthy controls.
Case-Control (n=62)
Even in mild aortic stenosis, patients exhibit significant cardiac remodeling and elevated filling pressures that are associated with markers of inflammation and myocardial fibrosis.
Absolute Event Rate: 32.4% vs 3.3%
p-value: p=0.003
The aim of the present study was to investigate the relationships among inflammation, myocardial fibrosis and cardiac remodelling in patients with mild aortic stenosis (AS), as assessed by biomarkers and echocardiography. 2. We evaluated 32 consecutive patients with mild AS, as well as 30 age- and gender-matched healthy individuals with normal aortic valves as control subjects. 3. Baseline echocardiography showed that the left ventricular (LV) mass index (111.3 ± 26.9 vs 94.5 ± 18.2 g/m(2); P = 0.006) and left atrial (LA) volume index (LAVI 27.5 ± 9.0 vs xx.x ± 5.2 mm(3)/mm(2); P = 0.005) were significantly higher in patients with mild AS. 4. Furthermore, LA enlargement (LAVI > 33 mm(3)/mm(2); 32.4% vs 3.3%; P = 0.003) and elevated LV filling pressure (E/e' > 15; 50.0% vs 23.3%; P = 0.036) were higher in patients with mild AS. 5. In patients with mild AS, stepwise, multivariate linear regression analysis revealed that the LV end-diastolic volume index was independently associated with matrix metalloproteinase (MMP)-1 (β = 0.371; P = 0.015), that the aortic valve mean pressure gradient was independently associated with MMP-2 (β = 0.19; P = 0.019), that MMP-2 was independently associated with transforming growth factor-β (β = 0.95; P < 0.001) and interleukin (IL)-1 (β = 0.17; P = 0.019) and that IL-1 was independently associated with tissue inhibitor of matrix metalloproteinase-1 (β = 0.68; P = 0.001). 6. Myocardial fibrosis in mild AS is independently associated with three factors: LV volume overload, aortic valve pressure overload and inflammation.
Park et al. (Tue,) conducted a case-control in Mild aortic stenosis (n=62). Mild aortic stenosis vs. Healthy individuals with normal aortic valves was evaluated on Left atrial enlargement (LAVI > 33 mm3/mm2) (p=0.003). Mild aortic stenosis was associated with significantly higher rates of left atrial enlargement (32.4% vs 3.3%; P=0.003) and elevated left ventricular filling pressure compared to healthy controls.