Key result
Cytomegalovirus seropositivity was independently associated with increased arterial stiffness in patients with chronic kidney disease, increasing pulse wave velocity by an adjusted mean of 0.67 m/s.
Why the study?
Is Cytomegalovirus (CMV) seropositivity associated with increased arterial stiffness in non-diabetic patients with chronic kidney disease?
Cross-Sectional (n=215)
Outcome assessors blinded
No
Is Cytomegalovirus (CMV) seropositivity associated with increased arterial stiffness in non-diabetic patients with chronic kidney disease?
Mean Difference: 0.67 (95% CI 0.04–1.21)
Absolute Event Rate: 9.7% vs 8.2%
p-value: p=0.03
Cytomegalovirus seropositivity is independently associated with increased arterial stiffness in patients with early-stage chronic kidney disease, suggesting a potential viral mechanism contributing to their elevated cardiovascular risk.
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Supports CMV-vascular link in CKD; hypothesis-generating, should not yet change practice.
Wall et al. (2013) conducted a cross-sectional in Chronic Kidney Disease (n=215). Cytomegalovirus seropositivity vs. Cytomegalovirus seronegativity was evaluated on Pulse wave velocity (m/s) (MD 0.67, 95% CI 0.04-1.21, p=0.03). Cytomegalovirus seropositivity was independently associated with increased arterial stiffness in patients with chronic kidney disease, increasing pulse wave velocity by an adjusted mean of 0.67 m/s.
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