Key result
In spontaneously hypertensive rats, trandolapril reduced pulse pressure and incremental elastic modulus significantly more than amlodipine for the same mean blood pressure reduction.
Why the study?
Does trandolapril reduce central pulse pressure and arterial stiffness more than amlodipine in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Trandolapril administered chronically to achieve… vs Amlodipine administered chronically to achieve…
Design
Preclinical
Authors
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Hypothesis-generating for ACEI effects on arterial stiffness; leaves open translation to human central hemodynamics.
Does trandolapril reduce central pulse pressure and arterial stiffness more than amlodipine in spontaneously hypertensive rats?
Trandolapril provides greater reduction in central pulse pressure and arterial stiffness compared to amlodipine in hypertensive rats, potentially mediated by changes in the fibronectin-integrin complex.
Kakou et al. (2009) studied Hypertension. Trandolapril vs. Amlodipine was evaluated on Carotid arterial systolic BP and pulse pressure, diameter, incremental elastic modulus, and Fn and alpha5beta1-integrin immunolabeling. In spontaneously hypertensive rats, trandolapril reduced pulse pressure and incremental elastic modulus significantly more than amlodipine for the same mean blood pressure reduction.
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