Why the study?
Does isradipine improve the function and structure of large arteries in spontaneously hypertensive rats?
Population
15-week-old adult spontaneously hypertensive rats and normotensive control Wistar-Kyoto rats
Comparison
Isradipine 3 mg/kg subcutaneously once a day for… vs Placebo
Design
Preclinical, randomly allocated
Follow-up
12 weeks
Authors
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May selectively improve arterial remodeling in hypertension models; leaves open LVH effects and human translation.
Does isradipine improve the function and structure of large arteries in spontaneously hypertensive rats?
In spontaneously hypertensive rats, chronic isradipine therapy normalizes arterial pressure and improves arterial wall mechanics and remodeling, but fails to regress left ventricular hypertrophy.
Lévy et al. (1994) studied this question.
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