Key result
Long-term benidipine treatment improved impaired endothelium-dependent relaxation in renal resistance arteries of spontaneously hypertensive rats by enhancing nitric oxide-mediated relaxation.
Why the study?
Does benidipine improve endothelial function in renal resistance arteries of spontaneously hypertensive rats compared to ecarazine?
Does benidipine improve endothelial function in renal resistance arteries of spontaneously hypertensive rats compared to ecarazine?
Benidipine, unlike ecarazine, improves endothelial function in the renal resistance arteries of hypertensive rats by enhancing nitric oxide-mediated relaxation.
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Animal findings on renal endothelial function after BP-lowering therapy are hypothesis-generating; leaves open clinical relevance in human hypertension.
Dohi et al. (1996) studied Hypertension. Benidipine vs. Ecarazine and normotensive reference (WKY) was evaluated on Endothelium-dependent relaxations induced by acetylcholine in renal resistance arteries. Long-term benidipine treatment improved impaired endothelium-dependent relaxation in renal resistance arteries of spontaneously hypertensive rats by enhancing nitric oxide-mediated relaxation.
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