Key result
Benidipine therapy significantly improved coronary flow reserve and microvascular remodeling in renovascular hypertensive rats, associated with increased nitrite production and eNOS mRNA expression.
Why the study?
Does benidipine improve eNOS activity and coronary circulation in renovascular hypertensive rats?
Does benidipine improve eNOS activity and coronary circulation in renovascular hypertensive rats?
Benidipine improves coronary flow reserve and microvascular remodeling in hypertensive rats, potentially via stimulation of eNOS activity and expression.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for benidipine on eNOS and coronary reserve in RHR; leaves open clinical translation.
Naohiko Kobayashi (1999) studied Renovascular hypertension (n=33). Benidipine vs. Vehicle-treated RHR and sham-operated rats was evaluated on Endothelial cell-type nitric oxide synthase (eNOS) activity, eNOS mRNA expression, coronary flow reserve, and microvascular remodeling. Benidipine therapy significantly improved coronary flow reserve and microvascular remodeling in renovascular hypertensive rats, associated with increased nitrite production and eNOS mRNA expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: