What question did this study set out to answer?

To determine whether chronic administration of the calcium antagonist benidipine reverses left ventricular hypertrophy while improving coronary flow reserve and microvascular remodeling in renovascular hypertensive rats.

November 1, 1997Journal of Hypertension

Effect of benidipine on microvascular remodeling and coronary flow reserve in two-kidney, one clip Goldblatt hypertension

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Why the study?

Does benidipine improve coronary flow reserve and microvascular remodeling in two-kidney, one clip Goldblatt hypertensive rats?

Population

Two-kidney, one clip Goldblatt hypertensive rats (4 weeks post-clipping)

Comparison

Benidipine for 6 weeks vs No treatment

Design

Preclinical

Follow-up

6 weeks

Authors

NKNaohiko KobayashiDokkyo Medical University KKK KobayashiYokohama City University KKKouichi KounoDokkyo University

Discussion

Member takes

Implication

Hypothesis-generating for benidipine in hypertensive microvascular disease; leaves open clinical translation and requires human trials.

Key Points

To determine whether chronic administration of the calcium antagonist benidipine reverses left ventricular hypertrophy while improving coronary flow reserve and microvascular remodeling in renovascular hypertensive rats.
Two-kidney, one clip (2K1C) Goldblatt hypertensive rats were assigned after 4 weeks of renal clipping to receive benidipine for 6 weeks or remain untreated.
Systemic hemodynamics and coronary blood flow at baseline and following carbochrome-induced vasodilation were measured in conscious rats using nonradioactive colored microspheres.
Capillary density, arteriolar wall-to-lumen ratio, and perivascular fibrosis were evaluated histologically in cardiac tissue using an image analyzer.
Benidipine treatment significantly lowered systemic blood pressure, reduced total peripheral resistance, and markedly decreased left ventricular mass compared to untreated hypertensive controls.
Impaired coronary flow reserve observed in untreated hypertensive rats was significantly improved following benidipine therapy.
Benidipine reversed microvascular remodeling by significantly increasing capillary density while decreasing the arteriolar wall-to-lumen ratio and perivascular fibrosis.

Structured PICO

Does benidipine improve coronary flow reserve and microvascular remodeling in two-kidney, one clip Goldblatt hypertensive rats?

Population

Two-kidney, one clip Goldblatt hypertensive rats (4 weeks post-clipping)

Intervention

Benidipine for 6 weeks

Comparator

No treatment

Outcome

Coronary flow reserve and microvascular remodeling (capillary density, wall:lumen ratio of arterioles, perivascular fibrosis)surrogate

In a rat model of renovascular hypertension, benidipine reverses cardiac hypertrophy and improves coronary flow reserve and microvascular remodeling.

Cite This Study

Kobayashi et al. (1997) studied this question.

synapsesocial.com/papers/6a7070f85671bbf00bc2b3bd https://doi.org/10.1097/00004872-199715110-00013

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Effect of benidipine on microvascular remodeling and coronary flow reserve in two-kidney, one clip Goldblatt hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of benidipine on microvascular remodeling and coronary flow reserve in two-kidney, one clip Goldblatt hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

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