Key result
Captopril and hydralazine fail to improve carotid artery distensibility in spontaneously hypertensive rats.
Why the study?
The effect of prolonged antihypertensive treatment on the elastic behaviour of the external carotid artery in spontaneously hypertensive rats was unclear.
Does captopril or hydralazine alter the elastic behaviour of the carotid artery in spontaneously hypertensive rats?
Comparison
Captopril or hydralazine treatment vs vehicle
Design
Preclinical study with continuous echo-tracking and pressure monitoring
Follow-up
6 weeks
Authors
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Captopril or hydralazine did not alter carotid distensibility in hypertensive rats; leaves open effects on arterial compliance in humans.
Does captopril or hydralazine alter the elastic behaviour of the carotid artery in spontaneously hypertensive rats?
In a rat model of hypertension, structural changes in the carotid artery do not necessarily alter its elastic behavior.
Hayoz et al. (1993) studied Hypertension. Captopril or hydralazine vs. Vehicle-treated SHR and normotensive WKY rats was evaluated on Distensibility-pressure curves of the carotid artery. Captopril or hydralazine treatment for 6 weeks did not significantly shift the distensibility-pressure curves of the carotid artery in spontaneously hypertensive rats compared to vehicle.
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