January 1, 1993Journal of Hypertension

Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats

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Population

Spontaneously hypertensive rats (SHR, n=20) and normotensive Wistar-Kyoto (WKY) rats (n=20)

Comparison

Local incubation with clentiazem vs Control conditions and potassium cyanide poisoning

Design

Preclinical

Authors

BVBernard I. L vyInserm LFLahcen El FertakInstitut Clinique de la Souris CPC Pieddeloup

Discussion

Member takes

Implication

Hypothesis-generating in rat models; leaves open whether clentiazem improves human arterial compliance.

Structured PICO

Population

Spontaneously hypertensive rats (SHR, n=20) and normotensive Wistar-Kyoto (WKY) rats (n=20)

Intervention

Local incubation with clentiazem (calcium blockade)

Comparator

Control conditions (before calcium blockade) and potassium cyanide (KCN) poisoning

Outcome

Pressure-volume relationships and carotid compliancesurrogate

Acute calcium blockade increases carotid arterial compliance independently of endothelium integrity in both normotensive and hypertensive rats.

Cite This Study

vy et al. (1993) studied this question.

synapsesocial.com/papers/6a20b0b552a81c8a3de51e97 https://doi.org/10.1097/00004872-199301000-00009

Topics

Hypertension management

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Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider