What question did this study set out to answer?

To evaluate the role of the endothelium and tissue cGMP signaling in modulating carotid arterial wall compliance and smooth muscle tone in spontaneously hypertensive rats compared to normotensive controls.

January 1, 1993Journal of Cardiovascular Pharmacology

Endothelium, Mechanical Compliance, and cGMP Content in the Carotid Artery from Spontaneously Hypertensive Rats

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Why the study?

Does endothelium removal affect carotid compliance and cGMP content in WKY and SHR rats?

Population

12-week-old Wistar-Kyoto rats and spontaneously hypertensive rats using an experimental model of in situ…

Comparison

Endothelium removal and potassium cyanide… vs Intact endothelium (control values)

Design

Preclinical

Authors

MLMarie LegrandInstitut de France JBJoëlle BénessianoCenter for Assessment BLBernard LévyVascular Medicine

Discussion

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Implication

Endothelial-cGMP modulation of carotid compliance in hypertensive rat models is hypothesis-generating; should not yet inform clinical practice.

Key Points

To evaluate the role of the endothelium and tissue cGMP signaling in modulating carotid arterial wall compliance and smooth muscle tone in spontaneously hypertensive rats compared to normotensive controls.
Evaluated static mechanical properties of in situ isolated carotid arteries across pressures ranging from 50 to 175 mm Hg in 12-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs).
Assessed carotid compliance and tissue cGMP levels before and after mechanical endothelium removal or smooth muscle tone abolition with potassium cyanide (KCN).
Baseline maximal carotid compliance was lower in SHRs than WKY rats (0.13 ± 0.03 vs. 0.22 ± 0.07 µL/mm Hg, p < 0.001), but increased by 45% in SHRs and 35% in WKY rats after KCN poisoning (p < 0.01).
Endothelium removal significantly increased operating carotid compliance by 37% in WKY rats (p < 0.01) and by 25% in SHRs (p < 0.01).
Intact carotid cGMP was higher in SHRs than WKY rats (30.3 ± 3.7 vs. 19.7 ± 2.3 fmol/mg, p < 0.02) and decreased following endothelium removal by 90% in SHRs (p < 0.001) compared to 28% in WKY rats (p < 0.02).

Structured PICO

Does endothelium removal affect carotid compliance and cGMP content in WKY and SHR rats?

Population

12-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs) using an experimental model of in situ isolated carotid arteries

Intervention

Endothelium removal and potassium cyanide (KCN) poisoning

Comparator

Intact endothelium (control values)

Outcome

Carotid compliance (CC) and cGMP contentsurrogate

The mechanical properties of the carotid artery wall are endothelium-dependent, with the cGMP pathway appearing more activated in spontaneously hypertensive rats compared to normotensive controls.

Cite This Study

Legrand et al. (1993) studied this question.

synapsesocial.com/papers/6a7ac17d14b028facf0e88a4 https://doi.org/10.1097/00005344-199321001-00006

Topics

Hypertension management

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Implication

Endothelial-cGMP modulation of carotid compliance in hypertensive rat models is hypothesis-generating; should not yet inform clinical practice.

Endothelium, Mechanical Compliance, and cGMP Content in the Carotid Artery from Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Endothelium, Mechanical Compliance, and cGMP Content in the Carotid Artery from Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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