July 1, 1992AJP Heart and Circulatory Physiology

cGMP pathway and mechanical properties of carotid artery wall in WKY rats and SHR: role of endothelium

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Population

16- to 18-wk-old Wistar-Kyoto (WKY) rats and age-matched spontaneously hypertensive rats (SHR)

Comparison

Local incubation with methylene blue (10 M, 20… vs Control conditions with intact endothelium

Design

Preclinical

Authors

MGMarina GrandUniversidad Nacional del Centro de la Provincia de Buenos Aires JBJoëlle BénessianoCenter for Assessment BLBernard LévyVascular Medicine

Discussion

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Implication

May indicate compensatory endothelial cGMP mechanisms in hypertension models; leaves open translation to human therapy.

Structured PICO

Population

16- to 18-wk-old Wistar-Kyoto (WKY) rats and age-matched spontaneously hypertensive rats (SHR)

Intervention

Local incubation with methylene blue (10(-5) M, 20 min) or mechanical removal of the endothelium

Comparator

Control conditions with intact endothelium

Outcome

Static mechanical properties (carotid compliance) and tissue cGMP contentsurrogate

The cGMP synthesis regulation in spontaneously hypertensive rats is highly endothelium-dependent, suggesting a compensatory mechanism against genetic abnormalities.

Cite This Study

Grand et al. (1992) studied this question.

synapsesocial.com/papers/6a88ebc7cd9902a7ca1264d2 https://doi.org/10.1152/ajpheart.1992.263.1.h61

View Full Paper

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cGMP pathway and mechanical properties of carotid artery wall in WKY rats and SHR: role of endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

cGMP pathway and mechanical properties of carotid artery wall in WKY rats and SHR: role of endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider