What is the clinical evidence from this study?

Study design: Other. Population: Hypertension. Intervention: Spontaneously hypertensive rats (SHR) vs. Normotensive Wistar Kyoto rats (WKY). Primary outcome: Basal levels and responses of cyclic GMP (cGMP) to acetylcholine (ACh) and sodium nitroprusside (SNP).

What question did this study set out to answer?

To evaluate basal and stimulated release of endothelium-derived relaxing factor and cyclic GMP formation in resistance vessels during the development of hypertension across different ages.

January 1, 1991Japanese Circulation Journal-english EditionOpen Access

Cyclic GMP formation of resistance vessel in the development of hypertension in spontaneously hypertensive rats.

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Key result

Basal cGMP formation in mesenteric arteries was significantly lower in 12- and 20-week-old spontaneously hypertensive rats compared to age-matched normotensive rats.

Population

Spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) at 8-, 12- and 20-weeks of age

Comparison

Infusions of graded doses of acetylcholine or… vs Normotensive Wistar Kyoto rats and basal levels…

Design

Preclinical

Authors

YIYoichi IzumiTeikyo University MMMASAYA MINATONihon University MSMasayoshi SomaNihon University

Discussion

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Implication

May link impaired basal EDRF release to hypertension progression in SHR; hypothesis-generating and should not yet inform clinical practice.

Key Points

To evaluate basal and stimulated release of endothelium-derived relaxing factor and cyclic GMP formation in resistance vessels during the development of hypertension across different ages.
Perfused isolated mesenteric arteries from 8-, 12-, and 20-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) with Krebs-Henseleit solution containing isobutyl methyl xanthine.
Quantified cyclic GMP (cGMP) levels in arterial effluent at baseline and following graded infusions of acetylcholine (ACh) or sodium nitroprusside (SNP).
Basal cGMP levels in mesenteric arteries were significantly lower in 12- and 20-week-old SHR compared to age-matched WKY controls.
A negative correlation occurred between basal cGMP levels and systolic blood pressure across all ages in SHR, but not in WKY.
Arterial cGMP responsiveness to acetylcholine showed no differences between SHR and WKY at any age, while responsiveness to sodium nitroprusside was markedly higher in 12-week-old SHR than in age-matched WKY.

Structured PICO

Population

Spontaneously hypertensive rats and normotensive Wistar Kyoto rats at 8, 12, and 20 weeks of age.

Exposure

Infusions of graded doses of acetylcholine or sodium nitroprusside in perfused mesenteric arteries

Comparator

Normotensive Wistar Kyoto rats (WKY) and basal levels before infusion

Outcome

Levels of cyclic GMP (cGMP) in effluents from perfused mesenteric arteriessurrogate

Reduced basal cGMP formation in resistance vessels of older spontaneously hypertensive rats suggests that decreased basal release of endothelium-derived relaxing factor is associated with the development of hypertension.

Cite This Study

Izumi et al. (1991) studied Hypertension. Spontaneously hypertensive rats (SHR) vs. Normotensive Wistar Kyoto rats (WKY) was evaluated on Basal levels and responses of cyclic GMP (cGMP) to acetylcholine (ACh) and sodium nitroprusside (SNP). Basal cGMP formation in mesenteric arteries was significantly lower in 12- and 20-week-old spontaneously hypertensive rats compared to age-matched normotensive rats.

synapsesocial.com/papers/6a8f53884524544972ec1aba https://doi.org/10.1253/jcj.55.721

Topics

Hypertension management

View Full Paper

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Implication

May link impaired basal EDRF release to hypertension progression in SHR; hypothesis-generating and should not yet inform clinical practice.

Cyclic GMP formation of resistance vessel in the development of hypertension in spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Cyclic GMP formation of resistance vessel in the development of hypertension in spontaneously hypertensive rats.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider