Population
Aortic smooth muscle cells and aortic rings from spontaneously hypertensive rats and normotensive…
Comparison
Stimulation with exogenous nitrovasodilators or… vs Normotensive Wistar-Kyoto rats compared to…
Design
Preclinical
Authors
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Enhanced cGMP response in hypertensive rat vessels; hypothesis-generating for guanylate cyclase changes and leaves open human relevance.
Smooth muscle cells from adult spontaneously hypertensive rats show enhanced cGMP accumulation in response to nitrovasodilators and endothelium-derived relaxing factor compared to normotensive controls, associated with higher mRNA levels of soluble guanylate cyclase.
Papapetropoulos et al. (1994) studied this question.
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