Key result
ETA antagonist BQ123 dilates carotid arteries and increases compliance in normotensive and hypertensive rats.
Why the study?
Does endothelin receptor antagonism alter the static mechanical properties of carotid arteries in normotensive and hypertensive rats?
Population
In vitro carotid arteries from 14-week-old Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)
Comparison
Incubation with selective ETA and ETB endothelin… vs Control conditions and complete abolition of…
Design
Preclinical
Authors
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ETA antagonism improves carotid compliance in rat models; leaves open translation to human vascular disease.
Does endothelin receptor antagonism alter the static mechanical properties of carotid arteries in normotensive and hypertensive rats?
Endothelin exerts a tonic stiffening effect on the in vitro common carotid artery via the ETA receptor, similarly in normotensive and hypertensive rats.
Giuseppe Marano (1999) studied Hypertension. ETA and ETB endothelin receptor antagonists (BQ123 and BQ788) vs. Control conditions and potassium cyanide (KCN) was evaluated on Carotid artery diameter, cross-sectional compliance, and distensibility. Local incubation with the ETA receptor antagonist BQ123 significantly dilated carotid arteries and increased compliance and distensibility in both normotensive and hypertensive rats.
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