Key result
Multidimensional strategies including structured exercise improve geriatric CVD care, cutting hospital admissions by ~25%.
Why the study?
Age-related changes, multiple comorbidities, and atypical presentations complicate CVD care in older adults, prompting the need to synthesize emerging diagnostic and therapeutic innovations into an integrated, age-sensitive framework.
Integrating computational risk models, novel biomarkers, nanotechnology, and exercise interventions offers a promising multidimensional strategy for managing cardiovascular disease in older adults.
May support multidimensional geriatric CVD strategies; leaves open randomized validation before practice change.
Background: Cardiovascular diseases (CVDs) remain the leading cause of death globally, especially among older adults whose age-related changes, multiple comorbidities, and atypical presentations complicate care.Emerging computational risk models, molecular biomarkers, nanotechnology-based diagnostics, and tailored exercise interventions are reshaping geriatric CVD management.Objective: This review synthesizes recent progress in four domains: Computational risk stratification, molecular biology-driven biomarkers, nanotechnologyenabled imaging and drug delivery, and exercise physiology applications to propose an integrated, agesensitive framework for improving cardiovascular outcomes in geriatric patients.Methods: A narrative literature search of PubMed, Embase, and major guideline repositories was performed for English-language studies published.We prioritized research reporting clinical efficacy, safety, and real-world implementation considerations in populations aged 65 years and older.Results: Advanced computational algorithms now predict major adverse cardiac events with over 85% accuracy.Novel circulating biomarkers such as microRNA panels are progressing through early clinical trials, offering more precise patient stratification.Nanoparticle-based contrast agents have demonstrated enhanced imaging sensitivity and reduced off-target toxicity, while targeted nanocarriers show promise for sitespecific drug delivery.Structured exercise programs, combining aerobic and resistance training, have been associated with 20-30% reductions in hospital admissions and significant preservation of functional capacity. Conclusion:The convergence of these four approaches presents a multidimensional strategy tailored to the needs of older adults with CVD.To realize their full potential, large-scale real-world validation studies and cost-effectiveness analyses are essential before these innovations can be adopted into routine geriatric cardiology practice.
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Prabhat et al. (2025) conducted a review in Cardiovascular diseases. Computational risk models, biomarkers, nanotechnology, and exercise interventions was evaluated. A multidimensional strategy including computational algorithms, novel biomarkers, nanotechnology, and structured exercise programs (which reduce hospital admissions by 20-30%) improves geriatric CVD care.
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