Underutilization of B-type Natriuretic Peptide: A Review of its Clinical Utility and Barriers to Adoption

Q: What is the clinical evidence from this study?

Study design: Review. Population: Heart failure. Intervention: B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing.

Renu Nagar; Shraddha Bhardwaj

doi:10.5005/jp-journals-10054-0358

September 11, 2026Indian Journal of Medical BiochemistryOpen Access

Underutilization of B-type Natriuretic Peptide: A Review of its Clinical Utility and Barriers to Adoption

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PICO

P

Population

Heart failure

I

Intervention / Comparator

B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing

Limitations

Interpretation is deeply complicated by non-cardiac confounders like aging, obesity, and renal impairment
Angiotensin receptor-neprilysin inhibitor (ARNI) therapy invalidates the use of active BNP for therapeutic monitoring
Lack of alignment across global manufacturing platforms contributes to inter-assay variability and clinical hesitation

Abstract

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Cite This Study

Nagar et al. (2026) conducted a review in Heart failure. B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing was evaluated.

synapsesocial.com/papers/6ad1157b00741cc3fba7d4a3 https://doi.org/10.5005/jp-journals-10054-0358

View Full Paper

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Underutilization of B-type Natriuretic Peptide: A Review of its Clinical Utility and Barriers to Adoption

PICO

Limitations

Abstract

Discussion

Cite This Study

Underutilization of B-type Natriuretic Peptide: A Review of its Clinical Utility and Barriers to Adoption

PICO

Limitations

Abstract

Discussion

Cite This Study

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