Deep breathing heart rate variability is associated with respiratory muscle weakness in patients with chronic obstructive pulmonary disease
Key result
In patients with COPD, maximal inspiratory pressure was significantly correlated with the inspiratory-expiratory difference in heart rate during deep breathing (r = 0.60, p<0.01).
Why the study?
Is respiratory muscle weakness associated with impaired cardiac autonomic control in patients with chronic obstructive pulmonary disease?
Population
10 patients with chronic obstructive pulmonary disease and 9 age-matched healthy volunteers.
Comparison
Evaluation of heart-rate variability at rest and… vs Age-matched healthy volunteers.
Design
Case-control
Authors
Discussion
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Implication
Association in COPD is hypothesis-generating; prospective trials needed before considering respiratory muscle training for autonomic control.
Study Design
Type
Cross-Sectional (n=19)
Multicenter
No
Structured PICO
Is respiratory muscle weakness associated with impaired cardiac autonomic control in patients with chronic obstructive pulmonary disease?
P
Population
19 male participants (10 with COPD and 9 healthy age-matched controls) evaluated in a single session to assess the influence of respiratory muscle strength on cardiac autonomic control.
E
Exposure
Evaluation of heart-rate variability (HRV) at rest and during respiratory sinusal arrhythmia maneuver (RSA-M).
C
Comparator
Age-matched healthy volunteers.
O
Outcome
Heart-rate variability (HRV) at rest and during respiratory sinusal arrhythmia maneuver (RSA-M), and correlation between maximal inspiratory pressure (MIP) and inspiratory-expiratory difference (DeltaIE).surrogate
Main Result
Effect estimate: r = 0.60
p-value: p=<0.01
In patients with COPD, inspiratory muscle weakness is significantly associated with impaired cardiac autonomic control, suggesting a potential role for respiratory muscle training in rehabilitation.
Limitations
- Measurement and control of the tidal volume during respiratory control was not carried out.
- Evaluation of complete lung function (static volumes) was not performed due to prohibitively expensive equipment.
Cite This Study
Reis et al. (2010) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=19). Chronic Obstructive Pulmonary Disease (COPD) vs. Healthy age-matched volunteers was evaluated on Correlation between maximal inspiratory pressure (MIP) and inspiratory-expiratory difference (ΔIE) during respiratory sinusal arrhythmia maneuver (r = 0.60, p=<0.01). In patients with COPD, maximal inspiratory pressure was significantly correlated with the inspiratory-expiratory difference in heart rate during deep breathing (r = 0.60, p<0.01).