Aortic root haemodynamics following David procedure: numerical analysis of 3-dimensional haemodynamics
Key result
The David procedure resulted in less favorable haemodynamics compared to native aortic roots, with elements exposed to high pressure and low shear stress for almost two-thirds of the cardiac cycle.
Why the study?
Does the David procedure alter 3-dimensional geometrical deformation and local haemodynamics compared to native aortic roots in a porcine model?
Structured PICO
Does the David procedure alter 3-dimensional geometrical deformation and local haemodynamics compared to native aortic roots in a porcine model?
P
Population
Experimental study on 10 domestic pigs undergoing the David procedure compared to 10 native aortic roots to evaluate local haemodynamical conditions.
I
Intervention
David procedure
C
Comparator
Native aortic roots
O
Outcome
3-dimensional geometrical deformation of the aortic root (torsion and tilt angle) and local haemodynamical conditions (pressure, flow, and shear stress)surrogate
The David procedure creates less favorable haemodynamics than native aortic roots, exposing the root elements to high pressure and low shear stress for a longer portion of the cardiac cycle.
Authors
Discussion
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Implication
Warrants caution in extrapolating David procedure results; leaves open need for human validation studies.
Cite This Study
Berdajs et al. (2016) studied Aortic root haemodynamics (n=20). David procedure vs. Native aortic roots was evaluated on 3-dimensional geometrical deformation of the aortic root, torsion, tilt angle, local pressure, flow, and shear stress. The David procedure resulted in less favorable haemodynamics compared to native aortic roots, with elements exposed to high pressure and low shear stress for almost two-thirds of the cardiac cycle.