Impact of the bicuspid aortic valve on aortic root haemodynamics: three-dimensional computed fluid dynamics simulation†
Population
10 pigs with bicuspid aortic valve, including n=5 with aortic valve stenosis and n=5 with insufficiency.
Design
Preclinical
Authors
Discussion
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Implication
Stenotic BAV hemodynamics may accelerate degeneration; hypothesis-generating for phenotype-specific mechanisms in humans.
Structured PICO
P
Population
10 pigs with bicuspid aortic valve (BAV), including n=5 with aortic valve stenosis (67 ± 3.5 kg) and n=5 with insufficiency (66.7 ± 4.4 kg).
I
Intervention
3-dimensional time- and pressure-dependent computed fluid dynamic modeling of the aortic root.
O
Outcome
Local shear stress and pressure profile on the elements of the aortic root.surrogate
Computed fluid dynamics modeling demonstrates that bicuspid aortic valves with stenosis generate higher shear stress and pressure during peak ejection compared to those with insufficiency, potentially accelerating leaflet degeneration.
Cite This Study
Berdajs et al. (2018) studied this question.