Determinants of end-systolic pressure-volume relations during acute regional ischemia in situ.
Why the study?
Does acute regional ischemia alter left ventricular end-systolic pressure-volume relations in open-chest dogs?
Structured PICO
Does acute regional ischemia alter left ventricular end-systolic pressure-volume relations in open-chest dogs?
P
Population
13 open-chest dogs (n=6 reflex-blocked with hexamethonium/vagotomy, n=7 unblocked)
I
Intervention
3-minute occlusion of circumflex or left anterior descending arteries (proximal or distal)
C
Comparator
Baseline state before occlusion
O
Outcome
Changes in in situ left ventricular end-systolic pressure-volume relations (ESPVRs) and end-systolic elastance (Ees)surrogate
Acute regional ischemia reduces the slope of the end-systolic pressure-volume relation in situ, a change that is highly dependent on baseline elastance.
Authors
Discussion
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Implication
Acute ischemia reduces ESPVR slope in canine models; leaves open translation to human contractility assessment.
Cite This Study
Kass et al. (1989) studied this question.