November 1, 1988CirculationOpen Access

Effects of load alteration and coronary perfusion pressure on regional end-systolic relations.

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Population

Paced open-chest pig hearts (n=10)

Comparison

Afterload alteration with intravenous… vs Baseline conditions and varying coronary…

Design

Preclinical

Authors

WMWilliam P. MillerMassachusetts Eye and Ear Infirmary BFBioarn P. FlygenringUniversity of Wisconsin–Madison SNS. H. NellisPennsylvania State University

Discussion

Member takes

Implication

Regional Emax/Ees should not yet guide contractility assessment; leaves open standardized afterload methods for future validation.

Structured PICO

Population

Paced open-chest pig hearts (n=10)

Intervention

Afterload alteration with intravenous phenylephrine and alteration of coronary perfusion pressure (45-155 mm Hg)

Comparator

Baseline conditions (before afterload alteration) and varying coronary perfusion pressures

Outcome

Regional end-systolic relations (regional Emax and Ees)surrogate

Regional end-systolic relations used to assess myocardial contractility are dependent on the method of afterload alteration, coronary perfusion pressure, and the definition of end systole.

Cite This Study

Miller et al. (1988) studied this question.

synapsesocial.com/papers/6a7c657f169fe1af7cc2bc27 https://doi.org/10.1161/01.cir.78.5.1299

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Effects of load alteration and coronary perfusion pressure on regional end-systolic relations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of load alteration and coronary perfusion pressure on regional end-systolic relations.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider