September 1, 1984Circulation ResearchOpen Access

Regional end-systolic pressure-length relationships using a volume-loading technique in the intact pig heart.

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Population

Intact pig heart model (n=8 for hysteresis evaluation, n=7 for intervention evaluation)

Comparison

Dobutamine, propranolol, or global ischemia vs Baseline (before treatments)

Design

Preclinical

Authors

WMWilliam P. MillerMassachusetts Eye and Ear Infirmary ALA. J. LiedtkeUniversity Hospital of Basel SNS. H. NellisPennsylvania State University

Discussion

Member takes

Implication

Complex regional-global elastance responses in animals; leaves open whether these indices specifically track contractility.

Structured PICO

Population

Intact pig heart model (n=8 for hysteresis evaluation, n=7 for intervention evaluation)

Intervention

Dobutamine (5-13 micrograms/kg per min), propranolol (6-51 micrograms/kg per min), or global ischemia (50% reduction in coronary flow)

Comparator

Baseline (before treatments)

Outcome

Maximum elastance-length and maximum elastance-diametersurrogate

Differences in regional and global elastance responses to inotropic interventions suggest a complex relationship between regional and global myocardial mechanics that may not specifically reflect changes in contractility.

Cite This Study

Miller et al. (1984) studied this question.

synapsesocial.com/papers/6a98f66de8ca4d2af6362aab https://doi.org/10.1161/01.res.55.3.326

View Full Paper

Ask AI

Bookmark

Regional end-systolic pressure-length relationships using a volume-loading technique in the intact pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regional end-systolic pressure-length relationships using a volume-loading technique in the intact pig heart.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider