Key result
Aged human aortic roots exhibited significant regional variations in structural stiffness and differed significantly from porcine tissues, suggesting porcine models may not be analogous.
Population
Human aortic roots (mean age 81 ± 8.74 years, n=10) and porcine aortic roots (6-9 months, n=10)
Comparison
Vessel pressure-inflation test tracking… vs Comparison between human and porcine tissues…
Design
Preclinical
Authors
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Porcine models warrant caution for aged human aortic valve testing; leaves open need for validated human tissue platforms in preclinical research.
Porcine aortic root tissues have significantly different mechanical properties compared to aged human tissues, which has implications for preclinical testing of transcatheter valves and valve-sparing procedures.
Li et al. (2013) studied Aortic root structural compliance (n=20). Human aortic roots vs. Porcine aortic roots was evaluated on Structural compliance and tissue stiffness. Aged human aortic roots exhibited significant regional variations in structural stiffness and differed significantly from porcine tissues, suggesting porcine models may not be analogous.
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