Why the study?
Are there significant differences in the biomechanical properties between aged human and porcine aortic tissues relevant for percutaneous aortic valve intervention?
Population
8 aged human hearts (mean age 90.1 ± 6.8 years) and 10 porcine hearts (6-9 months)
Comparison
Biaxial mechanical property quantification and… vs Comparison between aged human and porcine tissues
Design
Preclinical
Authors
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Questions porcine aortic model validity for TAVI biomechanics; hypothesis-generating and requires human tissue validation.
Are there significant differences in the biomechanical properties between aged human and porcine aortic tissues relevant for percutaneous aortic valve intervention?
Significant biomechanical and structural differences exist between aged human and porcine aortic tissues, questioning the validity of using porcine models to investigate biomechanics for percutaneous aortic valve interventions.
Martin et al. (2010) studied this question.
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