Key result
The step-size of myosin V was proportional to neck length for constructs containing 2, 4, 6, and 8 IQ motifs, providing strong support for the swinging lever-arm model of myosin motility.
Population
Myosin V constructs lacking the globular tail domain, with altered neck lengths (2, 4, 6, and 8 IQ motifs)
Comparison
Altering the length of the neck by adding or… vs Different neck lengths compared to each other
Design
Preclinical
Authors
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No immediate clinical implications; leaves open relevance of the lever-arm model to cardiac myosins.
The step-size of myosin V is proportional to the length of its neck, providing strong support for the swinging lever-arm model of myosin motility.
Sakamoto et al. (2005) studied this question. Altering neck length by adding or deleting IQ motifs in myosin constructs was evaluated on Step-size of individual IQ mutants. The step-size of myosin V was proportional to neck length for constructs containing 2, 4, 6, and 8 IQ motifs, providing strong support for the swinging lever-arm model of myosin motility.
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