Key result
Muscle activation in live mice increased sarcomere length dispersion by 33-96% compared to the passive state, with non-uniformities reaching up to 1.0 µm within a small segment of muscle.
p-value: p=<0.01
In intact whole muscle, sarcomere length dispersions increase substantially during activation, indicating that passive mean sarcomere lengths from a single location may not represent active muscle distribution.
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Passive sarcomere measurements may misrepresent active muscle behavior; leaves open relevance to human cardiac models.
Moo et al. (2018) studied Healthy (muscle physiology) (n=17). Electrical stimulation (muscle activation) vs. Relaxed (passive) state was evaluated on Sarcomere length dispersion (local coefficient of variation) (p=<0.01). Muscle activation in live mice increased sarcomere length dispersion by 33-96% compared to the passive state, with non-uniformities reaching up to 1.0 µm within a small segment of muscle.
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