August 22, 2003Proceedings of the Royal Society B Biological SciencesOpen Access

Dynamics of individual sarcomeres during and after stretch in activated single myofibrils

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Population

Single myofibrils isolated from rabbit psoas

Design

Preclinical

Authors

DRDilson E. RassierSimon Fraser University WHWalter HerzogHeart Failure & Transplant GPGerald H. PollackUniversity of Washington

Discussion

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Implication

Challenges sarcomere instability assumption on descending limb; leaves open translation to intact cardiac muscle mechanics.

Structured PICO

Population

Single myofibrils isolated from rabbit psoas

Intervention

Controlled stretching of activated myofibrils (stretches of 11.2 +/- 1.6% of SL at a speed of 118.9 +/- 5.9 nm s(-1), pCa(2+) = 4.75)

Outcome

Sarcomere length (SL) uniformity and stability during and after stretch

Sarcomeres in activated single myofibrils are non-uniform but generally stable on the descending limb of the force-length relationship, challenging the assumption of inherent instability.

Cite This Study

Rassier et al. (2003) studied this question.

synapsesocial.com/papers/6a76797aed4768d249c44831 https://doi.org/10.1098/rspb.2003.2418

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Dynamics of individual sarcomeres during and after stretch in activated single myofibrils

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dynamics of individual sarcomeres during and after stretch in activated single myofibrils

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider