Key result
Mechanics-centered models, emphasizing long-range interactions and criticality, are necessary to complement chemistry-centered models in understanding muscle force generation.
Population
Skeletal muscles (myofibrils, sarcomeres, actomyosin complexes)
Comparison
Mechanics-centered physical modeling of muscle… vs Chemistry-centered biochemical models
Design
Review
Authors
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Mechanics models may complement biochemical ones for muscle force; leaves open clinical relevance in cardiology.
This review demonstrates that purely biochemical models are insufficient to explain muscle contraction, and that mechanical models incorporating long-range interactions and criticality are necessary to understand active and passive force generation.
Caruel et al. (2017) conducted a review in Muscle contraction. Mechanics-centered models, emphasizing long-range interactions and criticality, are necessary to complement chemistry-centered models in understanding muscle force generation.
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